Ofloxacin is a synthetic fluoroquinolone antibiotic with potent antimicrobial activity against a wide range of gram-negative and gram-positive bacteria. It inhibits bacterial DNA gyrase and topoisomerase IV enzymes, disrupting DNA replication and leading to bacterial cell death. Available in oral, topical, and intravenous formulations, ofloxacin is commonly prescribed for the treatment of various infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and sexually transmitted diseases. Its broad spectrum of activity, favorable pharmacokinetics, and clinical efficacy make ofloxacin a valuable therapeutic option in both community and hospital settings.