2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, commonly known as HBTU, is a chemical compound widely used as a coupling reagent in peptide synthesis and other amide bond-forming reactions. This heterocyclic compound plays a crucial role in organic synthesis, particularly in the field of peptide chemistry, due to its ability to activate carboxylic acids and form highly reactive acylating intermediates, thereby facilitating efficient and selective amide bond formation.