Protein Kinase Supplement KT5823 CAS:126643-37-6

Protein kinase supplement KT5823 is a commonly used inhibitor of protein kinase G (PKG), specifically targeting the type I isoform PKG-1. PKG is a serine/threonine kinase that plays a critical role in various cellular processes such as smooth muscle relaxation, platelet aggregation, and regulation of vasodilation.

The main effect of KT5823 is the inhibition of PKG-1 activity by competing with ATP binding to the kinase domain. By inhibiting PKG-1, KT5823 can disrupt signaling pathways downstream of PKG-1 activation, including cGMP-dependent signaling cascades.

The application of KT5823 is primarily in research studies to investigate the function and signaling pathways of PKG-1. Its use in inhibiting PKG-1 activity allows researchers to explore the roles of PKG-1 in various physiological and pathological processes. Some specific applications of KT5823 include:

Investigating smooth muscle relaxation: PKG-1 plays a crucial role in smooth muscle relaxation. By inhibiting PKG-1 using KT5823, researchers can study the underlying mechanisms and pathways involved in smooth muscle relaxation, which is important in fields like cardiovascular research.

Studying platelet aggregation: PKG-1 also regulates platelet aggregation and clot formation. Inhibiting PKG-1 with KT5823 allows researchers to evaluate the impact of PKG-1 activity on platelet function and understand the pathways involved.

Exploring downstream targets of PKG-1: By inhibiting PKG-1, researchers can identify and study the downstream targets and effectors of PKG-1 signaling, providing insights into the molecular mechanisms underlying PKG-1-mediated cellular responses.