1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester CAS:147403-52-9
1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, methyl ester is synthesized through a series of organic reactions starting from commercially available precursors. The synthesis involves constructing the benzimidazole ring system, coupling it with the biphenylcarbonyl and oxadiazole groups, and then esterifying with methanol. These synthetic steps require precise control over reaction conditions to achieve optimal regioselectivity and yield of the final product. Synthetic Routes The synthesis begins with the preparation of the benzimidazole core through condensation reactions, followed by the incorporation of the biphenylcarbonyl and oxadiazole functionalities. The final step involves esterification with methanol to produce the methyl ester derivative. This approach ensures the compound is synthesized with high purity suitable for subsequent biological and pharmaceutical studies. Chemical Properties and Reactivity 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, methyl ester exhibits specific chemical properties due to its complex molecular structure. The benzimidazole core provides rigidity and potential for hydrogen bonding, while the biphenylcarbonyl and oxadiazole groups influence electronic properties and reactivity. These characteristics dictate its interactions in organic transformations and potential biological activities. Biological and Pharmacological Significance This compound shows promising biological activities, including antimicrobial, antifungal, and potentially anticancer properties. Its structural elements enable interactions with biological targets, suggesting applications in therapeutic interventions. By targeting specific biochemical pathways or cellular processes, it holds potential in drug discovery and development efforts. Applications in Medicinal Chemistry In medicinal chemistry, 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, methyl ester serves as a scaffold for designing analogs with enhanced pharmacological properties. Modifications around the benzimidazole, biphenylcarbonyl, and oxadiazole moieties can optimize potency, selectivity, and pharmacokinetic profiles, aiming to develop novel therapeutic agents with improved efficacy and reduced side effects. Conclusion 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, methyl ester represents a significant compound in medicinal chemistry due to its complex molecular structure and potential biological activities. Its synthesis pathways provide valuable insights into pharmaceutical development, highlighting its role in advancing drug discovery efforts. Ongoing research continues to explore its biological effects and expand its applications, underscoring its relevance in modern pharmacology and therapeutic innovation.
Composition | C26H22N4O5 |
Assay | 99% |
Appearance | white powder |
CAS No. | 147403-52-9 |
Packing | Small and bulk |
Shelf Life | 2 years |
Storage | Store in cool and dry area |
Certification | ISO. |