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(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol CAS:127852-28-2

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is a valuable chiral building block in organic synthesis, known for its significant applications in pharmaceutical and agrochemical industries. This compound is synthesized from (R)-3,5-bis(trifluoromethyl)acetophenone through reduction, resulting in a structurally important intermediate that facilitates the creation of various biologically active molecules.


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Application and Effect:

The structural composition of (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol highlights several key features: Chirality: It is optically active with a single chiral center, denoted as (R)-configuration. Phenyl Ring: Contains a phenyl ring substituted with two trifluoromethyl groups, imparting unique electronic properties favorable for interactions with biological targets. Hydroxyl Group: The presence of a hydroxyl group enhances solubility and can participate in hydrogen bonding interactions crucial for biological activity. Synthetic Utility: Its straightforward synthesis and chiral purity make it an ideal precursor for asymmetric synthesis of complex molecules. Pharmacological Significance The compound's pharmacological relevance stems from its structural attributes: Biological Activity: Analogous structures have shown activity as enzyme inhibitors, particularly in pharmaceuticals targeting metabolic pathways. Chirality Impact: The (R)-configuration influences interactions with enzymes and receptors, potentially enhancing specificity and potency of pharmacological effects. Versatile Applications: Used as a scaffold in drug design, it can be modified to optimize pharmacokinetic properties and therapeutic efficacy. Applications in Organic Synthesis In organic synthesis, (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol serves multiple roles: Chiral Synthesis: Enables the synthesis of enantiomerically pure compounds crucial in medicinal chemistry and agrochemical development. Intermediate Synthesis: Acts as a key intermediate in the production of insecticides, herbicides, and pharmaceuticals targeting specific biological pathways. Catalyst Development: Its chiral nature makes it valuable in asymmetric catalysis, facilitating the creation of complex molecular architectures with high efficiency. Conclusion In conclusion, (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is a pivotal compound in organic synthesis, prized for its chiral purity and versatile applications in drug discovery and development. Its unique structural attributes and pharmacological potential underscore its importance as a building block for creating biologically active molecules and fine chemicals. Ongoing research into its synthesis methodologies and pharmacological properties promises continued advancements in pharmaceuticals and related fields, further enhancing its role in modern chemistry and therapeutic innovation.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C10H8F6O
Assay 99%
Appearance white powder
CAS No.  127852-28-2
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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