(R)-2-Bromo-1-(4-fluorophenyl)ethanol CAS:1097211-38-5

(R)-2-Bromo-1-(4-fluorophenyl)ethanol is a chiral building block containing a 2-bromoethyl alcohol moiety bonded to a 4-fluorophenyl ring. The presence of the reactive alcohol and bromine groups, along with stereochemical complexity from the R-chirality center, allows this molecule to engage in diverse substitution, addition and resolution reactions.

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Application and Effect:

This versatile building block has numerous applications in pharmaceutical and material synthesis. The alcohol enables formation of ethers, esters, and tosylates through standard oxygen chemistry. Stereoselective substitutions on the bromine then generate various aryl motifs. It is also amenable to cross-coupling reactions to furnish diverse heterocycles. Such transformations provide a means to establish structure-activity relationships and develop drug leads. Additionally, it can act as a monomer in polymerizations to yield optically active materials. The multiple functional sites and intrinsic chirality render this compound an important synthon for producing bioactive agents and functional advanced materials.