(R)-(4-Fluorophenyl)oxirane CAS:134356-73-3

As a versatile intermediate, (R)-(4-fluorophenyl)oxirane enables efficient asymmetric synthesis of pharmaceuticals and biological probes. Stereoselective ring-opening with nucleophiles constructs targeted diastereomers applicable for biological evaluation and structure-activity studies. Reactions are facilitated by the electron-withdrawing fluorine atom. The simple structure allows for late-stage functionalization and manipulation. It also serves as a monomer for chiral polymeric materials. Moreover, agricultural prototypes may emerge from enantioselective ring-openings supplying stereochemically enriched intermediates. Therefore, through diastereoselective ring-opening of its strained epoxide, this enantiopure building block supports synthesis of drugs, agrochemicals and functional materials with well-defined stereochemistry.