((R,R)-2-AMINO-1,2-DIPHENYLETHYL)[(4-TOLYL)SULFONYL]AMIDO](P-CYMENE)RUTHENIUM(II)CHLORIDE CAS:192139-92-7

((R,R)-2-Amino-1,2-diphenylethyl)[(4-tolyl)sulfonyl]amido](p-cymene)ruthenium(II) chloride serves as a catalyst in various asymmetric transformations. One significant application is in asymmetric hydrogenation reactions, where it catalyzes the reduction of prochiral substrates to yield enantioenriched products with high selectivity. This reaction is valuable in the synthesis of pharmaceutical intermediates and chiral building blocks. Moreover, the complex is employed in asymmetric transfer hydrogenation reactions, enabling the reduction of prochiral ketones and imines using hydrogen donors such as formic acid or isopropanol. This process provides access to enantioenriched secondary alcohols and amines, which are important in organic synthesis and medicinal chemistry. Additionally, ((R,R)-2-Amino-1,2-diphenylethyl)[(4-tolyl)sulfonyl]amido](p-cymene)ruthenium(II) chloride finds applications in asymmetric allylic substitutions, facilitating the addition of nucleophiles to allylic substrates with high regio- and stereo-selectivity. This reaction is crucial in the synthesis of chiral compounds and natural products. Furthermore, the complex serves as a catalyst in asymmetric cyclopropanation reactions, enabling the formation of cyclopropane derivatives with high enantioselectivity. Cyclopropanes are versatile building blocks in organic synthesis, participating in various ring-opening and ring-expansion reactions. Moreover, ((R,R)-2-Amino-1,2-diphenylethyl)[(4-tolyl)sulfonyl]amido](p-cymene)ruthenium(II) chloride is utilized in asymmetric Heck reactions, enabling the coupling of aryl halides with olefins to form substituted alkenes with high stereoselectivity. This transformation is important in the synthesis of pharmaceuticals, agrochemicals, and materials. Additionally, the complex finds applications in asymmetric allylation reactions, facilitating the addition of allyl groups to electrophiles such as aldehydes and imines with high regio- and stereo-control. These reactions are valuable in the synthesis of complex molecules and natural products. In summary, ((R,R)-2-Amino-1,2-diphenylethyl)[(4-tolyl)sulfonyl]amido](p-cymene)ruthenium(II) chloride is a versatile catalyst employed in asymmetric hydrogenation, transfer hydrogenation, allylic substitutions, cyclopropanation, Heck reactions, and allylation reactions. Its applications span from the synthesis of chiral compounds to the construction of complex molecules, making it a valuable tool in asymmetric catalysis and organic synthesis.