Sodium 4-phenylbutyrate CAS:1716-12-7

Sodium 4-phenylbutyrate is an important organic compound that has garnered interest for its biological activities and therapeutic potential. With a molecular formula of C10H11NaO2, this compound is characterized by a sodium ion linked to the carboxylate group of 4-phenylbutyric acid, resulting in enhanced solubility and bioavailability. The structure consists of a four-carbon butyric acid chain with a phenyl substituent at the terminal position, contributing to its functional properties. One of the primary mechanisms by which sodium 4-phenylbutyrate exerts its effects is through its role as a histone deacetylase (HDAC) inhibitor. By inhibiting HDAC enzymes, this compound promotes the acetylation of histones, leading to altered chromatin structure and increased gene expression. This mechanism has implications in various fields, particularly oncology and neurology, where changes in gene expression are crucial for disease progression and treatment response. Sodium 4-phenylbutyrate has shown promise in preclinical studies for the treatment of neurodegenerative diseases, including Huntington's disease and amyotrophic lateral sclerosis (ALS). By mitigating cellular stress and promoting the survival of neurons, it may offer neuroprotective benefits. Additionally, it has been investigated for its potential use in metabolic disorders, such as urea cycle disorders, where it helps in the detoxification of ammonia. Moreover, sodium 4-phenylbutyrate has been explored for its applications in combination therapies, enhancing the efficacy of other treatments while reducing side effects. Its favorable safety profile and low toxicity further support its potential as a therapeutic agent. In summary, sodium 4-phenylbutyrate is a compound of considerable interest due to its multifaceted biological activities and potential therapeutic applications. Its role as a histone deacetylase inhibitor and its capacity to modulate cellular responses make it a valuable candidate for further research in the treatment of neurodegenerative diseases and metabolic disorders. As ongoing studies elucidate its mechanisms and effects, sodium 4-phenylbutyrate may play a significant role in advancing modern therapeutics.