Sodium-t-butoxide CAS:865-48-5

Sodium t-butoxide is a strong, non-nucleophilic base commonly used in organic synthesis. It is derived from sodium hydroxide and t-butanol, and appears as a white to off-white crystalline powder. In chemical reactions, it serves as a base due to its high basicity and is often employed in the deprotonation of various compounds, such as alcohols, phenols, and acidic protons adjacent to carbonyl groups. Additionally, it is utilized in the formation of carbon-carbon and carbon-heteroatom bonds, as well as in the synthesis of pharmaceuticals, agrochemicals, and materials chemistry.

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Application and Effect:

The versatile applications of sodium t-butoxide stem from its ability to catalyze numerous chemical transformations. These include the production of ethers, esters, and amides through Williamson ether synthesis, esterification, and amidation reactions, respectively. Furthermore, it facilitates the Claisen condensation and Knoevenagel condensation, vital processes in organic chemistry for the formation of carbon-carbon bonds. In addition, sodium t-butoxide plays a crucial role in the preparation of β-diketones, enol ethers, and other valuable intermediates. Its utility extends to the realm of pharmaceuticals, where it aids in the development of new drug candidates by enabling key synthetic steps. Overall, the wide-ranging uses of sodium t-butoxide underscore its significance in modern organic chemistry and industrial applications.

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Composition	C4H9NaO
Assay	99%
Appearance	white powder
CAS No.	865-48-5
Packing	Small and bulk
Shelf Life	2 years
Storage	Store in cool and dry area
Certification	ISO.