tert-Butyl 3,3,3-trifluoro-2-hydroxypropylcarbamate CAS:1219606-48-0

This compound has numerous applications in pharmaceutical, agrochemical and materials synthesis. The alcohol functionality can engage in dehydration, esterification and ether formation chemistry. Meanwhile, the carbamate permits derivatization at nitrogen. This diversifies heterocyclic building blocks for drug design. Under basic conditions, the carbamate hydrolyzes to a primary amine for alkylation or reductive amination. The fluorinated motif also induces lipophilicity for enhancing membrane permeability. These versatile properties establish it as a fundamental synthon for elaborating drug-like scaffolds and agrochemicals. It may find use in polymer chemistry as a monomer to give specialty materials with tunable properties.