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VALINOMYCIN CAS:2001-95-8 Manufacturer Price

Valinomycin is a natural cyclic peptide antibiotic that is primarily produced by certain strains of Streptomyces bacteria. It is composed of a cycle of alternating D- and L-amino acids, with a central cyclic depsipeptide motif. Valinomycin is well known for its high affinity for monovalent cations, particularly potassium ions (K+).

Due to its ability to selectively bind and transport potassium ions across biological membranes, valinomycin has found various applications in scientific research and biotechnology. It is widely used as an ionophore in ion-selective electrodes for measuring potassium concentrations in biological samples. Valinomycin’s unique ability to selectively transport potassium ions also makes it useful in studies of ion transport and membrane potential in cells.


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Application and Effect

Valinomycin primarily functions as an ionophore, meaning it facilitates the transport of specific ions across cell membranes. Its most notable effect is its strong affinity for potassium ions (K+). Valinomycin forms a complex with K+ ions, making it highly selective for their transport.

One of the main applications of valinomycin is as an ionophore in ion-selective electrodes for measuring potassium concentrations in biological samples. These electrodes exploit the ability of valinomycin to selectively bind and transport K+ ions, enabling accurate and sensitive potassium ion measurements.

Valinomycin's ability to transport potassium ions also makes it valuable in research related to ion transport and membrane potential in cells. It is used to study the role of ion channels, membrane potential, and ion gradients in various biological processes.

Moreover, valinomycin has been investigated for its potential therapeutic applications. It has shown promising results as an anticancer agent in certain types of cancer. Valinomycin induces apoptosis (cell death) in cancer cells by disrupting their mitochondrial membrane potential.

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试剂包装2

Additional Information:

Composition C54H90N6O18
Assay 99%
Appearance White powder
CAS No. 2001-95-8
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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